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Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate of <i>Escherichia coli</i> due to IS <i>26</i> -mediated amplification of <i>bla</i> <sub>TEM-1B</sub>

2020-03-03

Abstract excerpt

A novel phenotype of Escherichia coli and Klebsiella pneumoniae resistant to piperacillin/tazobactam (TZP), but susceptible to carbapenems and 3 rd generation cephalosporins has recently emerged. The resistance mechanism of this phenotype has been identified as hyperproduction of the β-lactamase bla TEM , however the mechanism of hyperproduction in isolates lacking promoter region mutations is not well understo...

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Literature Corpus work
44488f13-187a-5636-8802-967037838556
DOI
10.1101/2020.02.28.969360
Open publication

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Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate of <i>Escherichia coli</i> due to IS <i>26</i> -mediated amplification of <i>bla</i> <sub>TEM-1B</sub>DOI 10.1101/2020.02.28.969360
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