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Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B

1 Oct 2020

Abstract excerpt

Abstract A phenotype of Escherichia coli and Klebsiella pneumoniae , resistant to piperacillin/tazobactam (TZP) but susceptible to carbapenems and 3rd generation cephalosporins, has emerged. The resistance mechanism associated with this phenotype has been identified as hyperproduction of the β-lactamase TEM. However, the mechanism of hyperproduction due to gene amplification is not well understood. Here, we...

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PMID: 33004811
DOI: 10.1038/s41467-020-18668-2

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