Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

25 Sept 2019

Abstract excerpt

Filariae are parasitic nematodes that are transmitted to their definitive host as third-stage larvae by arthropod vectors like mosquitoes. Filariae cause diseases including: lymphatic filariasis with distressing and disturbing symptoms like elephantiasis; and river blindness. Filarial diseases affect millions of people in 73 countries throughout the topics and sub-tropics. The drugs available for mass drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helminth infection and control
Share to Parasite Biology and Host Interactions
Share to Parasitic Diseases Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31553770
DOI: 10.1371/journal.ppat.1008041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channelPMID 31553770Read ↗

Positive allosteric modulation of emodepside sensitive <i>Brugia malayi</i> SLO-1F and <i>Onchocerca volvulus</i> SLO-1A potassium channels by GoSlo-SR-5-69Semantic proximity Read ↗

Effects of Emodepside on Single-Channel Properties of Onchocerca volvulus SLO-1A (BK) Potassium ChannelsSemantic proximity Read ↗

Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasisSemantic proximity Read ↗

SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.Semantic proximity Read ↗

The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.Semantic proximity Read ↗

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito hostSemantic proximity Read ↗

Extracellular vesicles secreted by <i>Brugia malayi</i> microfilariae modulate the melanization pathway in the mosquito hostSemantic proximity Read ↗

Pharmacological profiling of a <i>Brugia malayi</i> muscarinic acetylcholine receptor as a putative antiparasitic targetSemantic proximity Read ↗

Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and TreatmentSemantic proximity Read ↗

Unveiling mode of action of anthelmintics in <i>Caenorhabditis elegans</i> with SydLab™, an on-a-chip automated and high-content screening systemSemantic proximity Read ↗

Deep phenotypic profiling uncovers cryptic effects of antifilarial drugsSemantic proximity Read ↗

Bma-LAD-2, an intestinal cell adhesion protein, as a potential therapeutic target for lymphatic filariasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.