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Article

SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

PLoS pathogens - 1 Apr 2011

Welz Claudia, Krüger Nina, Schniederjans Monika, Miltsch Sandra M, Krücken Jürgen, Guest Marcus, Holden-Dye Lindy, Harder Achim, von Samson-Himmelstjerna Georg

Abstract excerpt

The calcium-gated potassium channel SLO-1 in Caenorhabditis elegans was recently identified as key component for action of emodepside, a new anthelmintic drug with broad spectrum activity. In this study we identified orthologues of slo-1 in Ancylostoma caninum, Cooperia oncophora, and Haemonchus...

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Source

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Identifiers

PMID: 21490955
DOI: 10.1371/journal.ppat.1001330
PMCID: PMC3072372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21490955-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.PMID 21490955Read ↗

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