Article

Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of <i>WISP3</i> , the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood

2023-04-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC), caused by deficiency of WNT1 inducible signaling pathway protein 3 ( WISP3 ), has been challenging to study because no animal model of the disease exists and cartilage recovered from affected patients is indistinguishable from common end-stage osteoarthritis. Therefore, to gain insights into why precocious artic...

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Literature Corpus work: 441a59f7-c7f7-53c3-8878-bf581ae7ce1c
DOI: 10.1101/2023.04.01.535214

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