Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular and molecular responses in progressive pseudorheumatoid dysplasia articular cartilage associated with compound heterozygous WISP3 gene mutation.

Journal of molecular medicine (Berlin, Germany) - 1 Sept 2007

Zhou Hou-De, Bu Yan-Hong, Peng Yi-Qun, Xie Hui, Wang Min, Yuan Lin-Qing, Jiang Yi, Li Duo, Wei Qi-You, He Yu-Ling, Xiao Tao, Ni Jiang-Dong, Liao Er-Yuan

Abstract excerpt

Progressive pseudorheumatoid dysplasia (PPD) is characterized by continuous degeneration and loss of articular cartilage, which has been attributed to mutations in the gene encoding WISP3. We collected a PPD family and analyzed their WISP3 genes mutation. Articular chondrocytes (ACs) were purified from the femurs of a PPD patient after hip replacement surgery. Cell growth, proliferation, and viability were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Proteins

Share to Matrix Metalloproteinase 1

Share to Matrix Metalloproteinase 13

Share to Matrix Metalloproteinase 2

Share to Osteochondrodysplasias

Share to Radiography

Source

Identifiers

PMID: 17483925
DOI: 10.1007/s00109-007-0193-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular and molecular responses in progressive pseudorheumatoid dysplasia articular cartilage associated with compound heterozygous WISP3 gene mutation.PMID 17483925Read ↗

Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

Progressive pseudorheumatoid dysplasia with new-found gene mutation of Wntl inducible signaling pathway protein 3.Semantic proximity Read ↗

Patients with progressive pseudorheumatoid dysplasia: from clinical diagnosis to molecular studies.Semantic proximity Read ↗

Novel and recurrent mutations of WISP3 in two Chinese families with progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): a review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals.Semantic proximity Read ↗

Identification of novel mutations in WISP3 gene in two unrelated Chinese families with progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

Progressive pseudorheumatoid dysplasia involving a novel WISP3 mutation and sacroiliac and hip arthritis: A case report and literature review.Semantic proximity Read ↗

A novel WISP3 mutation in a Chinese patient with progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling.Semantic proximity Read ↗

WISP3‐dependent regulation of type II collagen and aggrecan production in chondrocytesSemantic proximity Read ↗

Late diagnosis of a truncating WISP3 mutation entails a severe phenotype of progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

A novel compound heterozygous mutation of WISP3 in progressive pseudorheumatoid dysplasia mimicking juvenile idiopathic arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.