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Article

Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.

Bone - 1 Apr 2018

Barruet Emilie, Hsiao Edward C

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a genetic condition characterized by massive heterotopic ossification. FOP patients have mutations in the Activin A type I receptor (ACVR1), a bone morphogenetic protein (BMP) receptor. FOP is a progressive and debilitating disease characterized by bone formation flares that often occur after trauma. Since it is often difficult or impossible to obtain large amounts...

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Share to Activin Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ossification, Heterotopic

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Source

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Identifiers

PMID: 28716551
DOI: 10.1016/j.bone.2017.07.003
PMCID: PMC5767535

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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