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Article

Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors.

Clinical rheumatology - 1 Jan 2017

Layh-Schmitt Gerlinde, Lu Shajia, Navid Fatemeh, Brooks Stephen R, Lazowick Emily, Davis Kathryn M, Montagna Cristina, Gadina Massimo, Colbert Robert A

Abstract excerpt

Axial spondyloarthritis (axSpA), which encompasses ankylosing spondylitis, is a complex genetic disease. Aberrant bone formation is a key feature of pathogenesis that can lead to ankylosis of the spine. Our objective is to determine, whether genes whose variants confer susceptibility to AS are expressed in bone progenitors like mesenchymal stem cells (MSCs). Since MSCs from bone marrow is difficult to obtain, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spondylitis, Ankylosing

Source

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Identifiers

PMID: 27864696
DOI: 10.1007/s10067-016-3469-5
PMCID: PMC5216109

Genes

ANO6
ANTXR2
EDIL3
HAPLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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