Article
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood.
Annals of the rheumatic diseases - 1 Dec 2023
Li Chaochang, Alemany-Ribes Mireia, Raftery Rosanne M, Nwoko Uzochi, Warman Matthew L, Craft April M
Abstract excerpt
OBJECTIVES: Progressive pseudorheumatoid arthropathy of childhood (PPAC), caused by deficiency of WNT1 inducible signalling pathway protein 3 (WISP3), has been challenging to study because no animal model of the disease exists and cartilage recovered from affected patients is indistinguishable from common end-stage osteoarthritis. Therefore, to gain insights into why precocious articular cartilage failure occurs...
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