Article

Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer

2024-08-08

Abstract excerpt

Abundant infiltration of tumor-associated macrophages (TAMs) within the tumor stroma plays a pivotal role in inducing immune escape in pancreatic cancer (PC). Lactate serves as a direct regulator of macrophage polarization and functions, although the precise regulation mechanism remain inadequately understood. Our study revealed that PC cells promote macrophage polarization towards the M2d phenotype through high l...

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Literature Corpus work: 36e717d2-d8b8-5435-bef2-0204a7153fda
DOI: 10.1101/2024.08.07.24311609

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