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Article

Mutational dissection of HCMV gB and gH cytoplasmic tails highlights conserved and divergent features of fusion regulation.

mBio - 12 Nov 2025

Lee Chanyoung, DiBella Hannah K, Heldwein Ekaterina E

Abstract excerpt

In herpesviruses, the fusogenic activity of the conserved glycoproteins gB and gH is regulated by their cytoplasmic (or intraviral) tails. However, prior to this work, their regulatory mechanisms had only been investigated in Alpha- and Gamma- but not in Betaherpesvirinae. Here, we developed a plasmid-transfection-based split-luciferase assay as a quantitative platform for measuring cell-cell fusion mediated by...

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Identifiers

PMID: 40981481
DOI: 10.1128/mbio.01905-25
PMCID: PMC12607583

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