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Next-Generation Analogues of AC265347 as Positive Allosteric Modulators of the Calcium-Sensing Receptor: Pharmacological Investigation of Structural Modifications at the Stereogenic Centre

2024-12-25

Abstract excerpt

The calcium-sensing receptor (CaSR) is a validated therapeutic target in the treatment of hyperparathyroidism and related diseases. The CaSR ago-positive allosteric modulator (PAM), AC265347 (1), exhibits a chemically and pharmacologically unique profile compared to current approved CaSR PAM therapeutics. Herein we report a series of ‘next-generation’ analogues of AC265347 investigating the impact of structural mo...

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Literature Corpus work
439bb593-8cc7-589e-afd6-6d19e1fc1dce
DOI
10.20944/preprints202412.2191.v1
Open publication

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Next-Generation Analogues of AC265347 as Positive Allosteric Modulators of the Calcium-Sensing Receptor: Pharmacological Investigation of Structural Modifications at the Stereogenic CentreDOI 10.20944/preprints202412.2191.v1
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