Article
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.
Cell death and differentiation - 1 Oct 2022
Chen Zhuoyao, Ioris Rafael M, Richardson Stacey, Van Ess Ava N, Vendrell Iolanda, Kessler Benedikt M, Buffa Francesca M, Busino Luca, Clifford Steven C, Bullock Alex N, D'Angiolella Vincenzo
Abstract excerpt
Medulloblastoma is the most common malignant brain tumour in children. Genomic studies have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for their subgroups, whereas those for non-WNT/non-SHH tumours remain largely elusive. Recent analyses have revealed...
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