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Article

Longitudinal Study of TCF4 CTG Trinucleotide Repeat Length and Disease Severity in Fuchs' Endothelial Corneal Dystrophy.

Medical sciences (Basel, Switzerland) - 7 Jan 2026

Teo Jasmin X J, Neo Dawn J H, Choo Jessica Q H, Gong Xin, Li Zheng, Htoon Hla Myint, Chua Min Jie, Soh Yu Qiang, Mootha V Vinod, Khor Chiea Chuen, Mehta Jodhbir S

Abstract excerpt

Objective: This was a longitudinal study of TCF4 CTG18.1 trinucleotide repeat lengths in 17 patients (27 eyes) diagnosed with Fuchs' endothelial corneal dystrophy (FECD), and it aimed to correlate the repeat expansion status with disease severity and progression. Design: This was a prospective cohort study looking at FECD clinical progression and TCF4 CTG18.1 repeat length expansion status over time. Methods: A...

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Identifiers

PMID: 41562921
DOI: 10.3390/medsci14010031
PMCID: PMC12821436

Genes

TCF4
ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Longitudinal Study of TCF4 CTG Trinucleotide Repeat Length and Disease Severity in Fuchs' Endothelial Corneal Dystrophy.PMID 41562921Read ↗

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