Highly specific σ ₂ R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response

Abstract excerpt

The Sigma 2 receptor (σ 2 R) was described pharmacologically more than three decades ago, but its molecular identity remained obscure until recently when it was identified as transmembrane protein 97 (TMEM97). We and others have shown that σ 2 R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal anti-nociceptive effect is approximately 24 hour...

Topics

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• Apelin-related biomedical research
• Hereditary Neurological Disorders
• Histone Deacetylase Inhibitors Research
• Nerve injury and regeneration
• Neuropeptides and Animal Physiology
• Pain Management and Opioid Use
• Pain Mechanisms and Treatments
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

513fcb8e-45c0-560d-b655-c2703ea74aa2

DOI

10.1101/2023.04.11.536439