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Galectin-1 Modulates Cell Adhesions, Caveolae, and Vascular Permeability in Kidney Endothelial Cells – Insights from Proteomics, Phosphoproteomics, and Functional Studies

2026-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Microvascular inflammation and endothelial injury, triggered by interferon-gamma (IFNγ), are hallmarks of antibody-mediated rejection (ABMR), the leading cause of premature kidney allograft loss. Glomerular extracellular matrix (ECM) remodeling and endothelial caveolae formation are important aspects of chronic ABMR. We found galectin-1, an immunomodulatory protein that interacts with the ECM, t...

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Literature Corpus work: 433500c3-cc1a-553f-b298-841c5db1f44e
DOI: 10.64898/2026.03.03.709385

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