An update on the pathogenesis and treatment of IgA nephropathy.

doi:10.1038/ki.2011.501

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Article

An update on the pathogenesis and treatment of IgA nephropathy.

Kidney international - 1 May 2012

Boyd Joanna K, Cheung Chee K, Molyneux Karen, Feehally John, Barratt Jonathan

Abstract excerpt

Over the past two decades significant progress has been made in unravelling the complex pathogenesis of immunoglobulin A nephropathy (IgAN). Excess amounts of poorly galactosylated immunoglobulin (Ig)A1 in the serum appear to be the trigger for generation of glycan-specific IgG and IgA autoantibodies, resulting in the formation of circulating IgA immune complexes, which are pivotal to the development of...

Topics

Animals
Antigen-Antibody Complex
Antihypertensive Agents
Autoantibodies
Evidence-Based Medicine
Genetic Predisposition to Disease
Glomerulonephritis, IGA
Glycosylation
Humans
Immunoglobulin A
Immunosuppressive Agents
Kidney
Protein Processing, Post-Translational
Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 22318424
DOI: 10.1038/ki.2011.501

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