Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating a Polygenic Risk Score into a clinical setting would impact risk predictions in familial breast cancer.

Journal of medical genetics - 19 Jan 2024

Baliakas Panagiotis, Munters Arielle R, Kämpe Anders, Tesi Bianca, Bondeson Marie-Louise, Ladenvall Claes, Eriksson Daniel

Abstract excerpt

BACKGROUND: Low-impact genetic variants identified in population-based genetic studies are not routinely measured as part of clinical genetic testing in familial breast cancer (BC). We studied the consequences of integrating an established Polygenic Risk Score (PRS) (BCAC 313, PRS313) into clinical sequencing of women with familial BC in Sweden. METHODS: We developed an add-on sequencing panel to capture 313 risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer Genomics and Diagnostics

Share to Genetic factors in colorectal cancer

Share to Genetic Predisposition to Disease

Share to Genetic Risk Score

Share to Genetic Testing

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37580114
DOI: 10.1136/jmg-2023-109311
PMCID: PMC10850617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating a Polygenic Risk Score into a clinical setting would impact risk predictions in familial breast cancer.PMID 37580114Read ↗

Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.Semantic proximity Read ↗

Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.Semantic proximity Read ↗

Polygenic scores in Familial breast cancer cases with and without pathogenic variants and the risk of contralateral breast cancerSemantic proximity Read ↗

Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.Semantic proximity Read ↗

Limitations in next-generation sequencing-based genotyping of breast cancer polygenic risk score lociSemantic proximity Read ↗

Limitations in next-generation sequencing-based genotyping of breast cancer polygenic risk score loci.Semantic proximity Read ↗

Genomic risk prediction for breast cancer in older womenSemantic proximity Read ↗

The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.Semantic proximity Read ↗

Population-specific validation and comparison of the performance of 77- and 313-variant polygenic risk scores for breast cancer risk prediction.Semantic proximity Read ↗

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.Semantic proximity Read ↗

Polygenic risk scores to refine Breast cancer screening and prevention strategies.Semantic proximity Read ↗

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.