Article
A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy.
Molecular neurodegeneration - 25 Jun 2021
Gutierrez-Quiceno Laura, Dammer Eric B, Johnson Ashlyn Grace, Webster James A, Shah Rhythm, Duong Duc, Yin Luming, Seyfried Nicholas T, Alvarez Victor E, Stein Thor D, McKee Ann C, Hales Chadwick M
Abstract excerpt
BACKGROUND: There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypothesized that identifying the human brain proteome from serial CTE stages (CTE I-IV) would provide...
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