Loss of heterozygosity in human skin.

doi:10.1016/s0190-9622(99)70042-3

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Article

Loss of heterozygosity in human skin.

Journal of the American Academy of Dermatology - 1 Aug 1999

Happle R

Abstract excerpt

Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell becomes either homozygous or hemizygous because the corresponding wild-type allele is lost. LOH has today been recognized as a major cause of malignant growth. This article gives a comprehensive review of skin disorders in which an origin from LOH has been either documented at the molecular level or postulated on the basis of...

Topics

Animals
Female
Genes, Dominant
Genes, Recessive
Homozygote
Humans
Loss of Heterozygosity
Male
Mutation
Plants
Skin Diseases, Genetic
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 10426882
DOI: 10.1016/s0190-9622(99)70042-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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