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Article

Loss of heterozygosity in human skin.

Journal of the American Academy of Dermatology - 1 Aug 1999

Happle R

Abstract excerpt

Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell becomes either homozygous or hemizygous because the corresponding wild-type allele is lost. LOH has today been recognized as a major cause of malignant growth. This article gives a comprehensive review of skin disorders in which an origin from LOH has been either documented at the molecular level or postulated on the basis of...

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Identifiers

PMID: 10426882
DOI: 10.1016/s0190-9622(99)70042-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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