Article

Oncogenes and tumor suppressor genes are enriched in stop-loss mutations generating protein extensions

2026-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Cancer genomes tend to accumulate a large number of mutations, and even rare mutations such as those causing the loss of a stop codon can be observed in a significant fraction of the tumors. Stop-loss mutations extend protein translation into the 3’ untranslated region (3’ UTR), generating altered proteins carrying extra amino acid sequences. These C-terminal extensions can potentially have cons...

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Literature Corpus work: 425d2a03-9df3-5576-933b-1c7259d3d4a2
DOI: 10.64898/2026.03.12.711331

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