Article
A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation.
Nature cell biology - 1 Aug 2020
Dhamija Sonam, Yang Chul Min, Seiler Jeanette, Myacheva Ksenia, Caudron-Herger Maiwen, Wieland Angela, Abdelkarim Mahmoud, Sharma Yogita, Riester Marisa, Groß Matthias, Maurer Jochen, Diederichs Sven
Abstract excerpt
Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3' untranslated region as a nonstop extension mutation to the next in-frame stop codon or as a readthrough mutation into the poly-A tail. Nonstop mutations have been characterized in hereditary diseases, but not in cancer genetics. In a pan-cancer analysis, we curated and analysed 3,412 nonstop mutations from 62...
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