Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p.

doi:10.1182/blood-2010-05-286534

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Article

Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p.

Blood - 2 Dec 2010

Gunay-Aygun Meral, Zivony-Elboum Yifat, Gumruk Fatma, Geiger Dan, Cetin Mualla, Khayat Morad, Kleta Robert, Kfir Nehama, Anikster Yair, Chezar Judith, Arcos-Burgos Mauricio, Shalata Adel, Stanescu Horia, Manaster Joseph, Arat Mutlu, Edwards Hailey, Freiberg Andrew S, Hart P Suzanne, Riney Lauren C, Patzel Katherine, Tanpaiboon Pranoot, Markello Tom, Huizing Marjan, Maric Irina, Horne McDonald, Kehrel Beate E, Jurk Kerstin, Hansen Nancy F, Cherukuri Praveen F, Jones Marypat, Cruz Pedro, Mullikin Jim C, Nurden Alan, White James G, Gahl William A, Falik-Zaccai Tzippora

Abstract excerpt

Gray platelet syndrome (GPS) is an inherited bleeding disorder characterized by macrothrombocytopenia and absence of platelet α-granules resulting in typical gray platelets on peripheral smears. GPS is associated with a bleeding tendency, myelofibrosis, and splenomegaly. Reports on GPS are limited to case presentations. The causative gene and underlying pathophysiology are largely unknown. We present the results...

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Identifiers

PMID: 20709904
DOI: 10.1182/blood-2010-05-286534
PMCID: PMC3012593

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