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Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

1 Mar 2024

Abstract excerpt

T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 38492218
DOI: 10.1016/j.celrep.2024.113963

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