Article

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

2020-12-02

Abstract excerpt

Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells encoding humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the sple...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0ed2b62-9fb6-59fd-b98f-92f38d9dc5dd
DOI: 10.1101/2020.12.01.407015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissuesDOI 10.1101/2020.12.01.407015Read

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissuesSemantic proximity Read

B cell clonal expansion and convergent antibody responses to SARS-CoV-2Semantic proximity Read

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2Semantic proximity Read

Convergent Sequence Features of Antiviral B CellsSemantic proximity Read

COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral TargetsSemantic proximity Read

Memory B cells dominate the early antibody-secreting cell response to SARS-CoV-2 mRNA vaccination in naïve individuals independently of their antibody affinitySemantic proximity Read

Maturation and persistence of the anti-SARS-CoV-2 memory B cell responseSemantic proximity Read

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2Semantic proximity Read

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clonesSemantic proximity Read

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seqSemantic proximity Read

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infectionSemantic proximity Read

Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccinationSemantic proximity Read