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Article

Maternal choline intake alters the epigenetic state of fetal cortisol‐regulating genes in humans

1 May 2012

Abstract excerpt

ABSTRACT The in utero availability of methyl donors, such as choline, may modify fetal epigenetic marks and lead to sustainable functional alterations throughout the life course. The hypothalamic‐pituitaryadrenal (HPA) axis regulates cortisol production and is sensitive to perinatal epigenetic programming. As an extension of a 12‐wk dose‐response choline feeding study conducted in third‐trimester pregnant women,...

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PMID: 22549509
DOI: 10.1096/fj.12-207894

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