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Article

Transgenerational epigenetic inheritance in mammals: how good is the evidence?

1 Apr 2016

Abstract excerpt

Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are modified throughout life in response to environmental and behavioral influences. With each new generation, DNA methylation patterns are erased in gametes and reset after fertilization, probably to prevent these epigenetic marks from being...

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PMID: 27037350
DOI: 10.1096/fj.201500083

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