Prenatal choline supplementation enhances metabolic outcomes with differential impact on DNA methylation in Wistar rat offspring and dams

Abstract excerpt

• Prenatal extra choline produced offspring with lower body weight and food intake. • Offspring of choline-supplemented dams had higher insulin sensitivity. • Dams supplemented with choline had higher hepatic Irs2 gene expression compared to the control. • Choline supplementation during pregnancy led to higher hepatic Irs2 gene expression in female offspring and lower Irs1 gene expression in male offspring...

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