Article

Lactylation drives tumor microenvironment remodeling and immune evasion in esophageal cancer revealed by multiomics and single cell transcriptomics

2025-11-23

Abstract excerpt

<title>Abstract</title> <p> <bold>Objectives:</bold> This study aimed to investigate the prognostic value of lactate metabolism-related genes (LMRGs) in esophageal cancer (EC), exploring their roles in tumor microenvironment (TME) remodeling, immunotherapy response, and potential therapeutic targeting. <bold>Methods:</bold> Multi-omics analysis integrated bulk RNA-seq (TCGA, GEO) and single-cell RNA-seq (scRN...

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Literature Corpus work: a1147937-f70d-5ff8-98d6-377961f65149
DOI: 10.21203/rs.3.rs-7809424/v1

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