Article

Sirolimus plus nintedanib treats vascular pathology in HHT mouse models

2019-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1-ENG-Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K-Akt-mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse mod...

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Literature Corpus work: 4214c567-030b-551d-a058-33cb5a99f2d4
DOI: 10.1101/739144

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