Article

Abnormal Angiogenesis and Therapeutic Targeting of VEGF, FGFR and PI3K/AKT/mTOR Signalling Pathways in Hereditary Haemorrhagic Telangiectasia: A Translational Narrative Review

2026-06-17

Abstract excerpt

<h4>Background: </h4> Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder characterised by abnormal angiogenesis resulting from dysregulation of the BMP9/10–ALK1–ENG–SMAD signalling axis. The disease is clinically characterised by recurrent epistaxis, iron-deficiency anaemia, gastrointestinal bleeding and visceral arteriovenous malformations. Increasing knowledge of the molecula...

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Literature Corpus work: 08009f28-fd82-536a-944d-32badb8655b5
DOI: 10.20944/preprints202606.1301.v1

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