Article

Specific oncogene activation of the cell of origin in mucosal melanoma

2024-04-26

Abstract excerpt

Mucosal melanoma (MM) is a deadly cancer derived from mucosal melanocytes. To test the consequences of MM genetics, we developed a zebrafish model in which all melanocytes experienced CCND1 expression and loss of PTEN and TP53. Surprisingly, melanoma only developed from melanocytes lining internal organs, analogous to the location of patient MM. We found that zebrafish MMs had a unique chromatin landscape from cut...

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Identifiers and source

Literature Corpus work: 42029ae5-15f0-59ac-8812-c0e2d16cfa73
DOI: 10.1101/2024.04.22.590595

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