Article
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Cell cycle (Georgetown, Tex.) - 15 Jun 2008
Rossi Giacomina, Dalprà Leda, Crosti Francesca, Lissoni Sara, Sciacca Francesca L, Catania Marcella, Di Fede Giuseppe, Mangieri Michela, Giaccone Giorgio, Croci Danilo, Tagliavini Fabrizio
Abstract excerpt
Tau is a microtubule-associated protein that promotes assembly and stabilization of cytoskeleton microtubules. It is mostly expressed in neuronal and glial cells but it is also present in non-neural cells such as fibroblasts and lymphocytes. An altered tau produces cytoskeleton pathology resulting in neurodegenerative diseases such as Alzheimer's disease and tauopathies. Tau has been suggested to be a...
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