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Article

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Molecular psychiatry - 1 Aug 2020

Amal Haitham, Barak Boaz, Bhat Vadiraja, Gong Guanyu, Joughin Brian A, Wang Xin, Wishnok John S, Feng Guoping, Tannenbaum Steven R

Abstract excerpt

Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome. Shank3 disruption in mice leads to dysfunction of synaptic transmission, behavior, and development. Protein S-nitrosylation, the nitric oxide (NO•)-mediated posttranslational modification (PTM) of cysteine thiols (SNO), modulates the...

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Identifiers

PMID: 29988084
DOI: 10.1038/s41380-018-0113-6
PMCID: PMC6614015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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