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Article

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism

9 Dec 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) arises from the combined degeneration of motor neurons (MN) and corticospinal neurons (CSN). Recent clinical and pathological studies suggest that ALS might start in the motor cortex and spread along the corticofugal axonal projections (including the CSN), either via altered cortical excitability and activity or via prion-like propagation of misfolded proteins. Using mouse...

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PMID: 33309802
DOI: 10.1016/j.pneurobio.2020.101972

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