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Genetic ablation of <i> SOD1 <sup>G37R</sup> </i> selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression

2020-01-10

Abstract excerpt

While clinical evidence of combined degeneration of the bulbar and spinal motor neurons (MN) together with the corticospinal neurons (CSN) is required to diagnose Amyotrophic Lateral Sclerosis (ALS), preclinical studies have mostly concentrated on MN, leaving aside the CSN and their contribution to ALS onset and progression. Recent studies carried on ALS patients suggest that the disease may initiate in the motor...

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Literature Corpus work
ef988e65-cc18-5311-8c67-8b3e4b42fde0
DOI
10.1101/2020.01.09.900944
Open publication

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Genetic ablation of <i> SOD1 <sup>G37R</sup> </i> selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progressionDOI 10.1101/2020.01.09.900944
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