Article

Locomotor deficits in ALS mice are paralleled by loss of V1-interneuron-connections onto fast motor neurons

2020-06-23

Abstract excerpt

ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle fibers exhibit preferential degeneration. The reason for differential vulnerability of fast motor neurons, and its consequence on motor output is not known. Here, we show that fast motor neurons receive more inhibitory synaptic inputs than slow motor neurons, and loss of inhibitory synapses onto fast mo...

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Identifiers and source

Literature Corpus work: 6695d873-50c0-5245-83f4-b75d9a30cc06
DOI: 10.1101/2020.06.23.166389

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