Article

Integration of polygenic risk with single cell methylation profiles for depression

2025-03-14

Abstract excerpt

Large scale genome-wide association studies (GWAS) have identified hundreds of risk loci for major depression disorder (MDD) with their functional understanding being largely unknown. We integrate MDD polygenic risk from GWAS with methylation at a single cell level resolution to gain insights into the role of methylation in driving MDD risk. We introduce a new approach that leverages the polygenic risk of disease...

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Literature Corpus work: 4151f87a-6e6a-5be3-91f4-c514e2e4167c
DOI: 10.1101/2025.03.11.642615

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