Article

Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-κB binding

2022-10-26

Abstract excerpt

Transposable elements (TEs) provide a source of transcription factor binding sites that can rewire conserved gene regulatory networks. NF-κB is an evolutionary conserved transcription factor complex primarily involved in innate immunity and inflammation. The extent to which TEs have contributed to NF-κB responses during mammalian evolution is not well established. Here we performed a multi-species analysis of TEs...

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Literature Corpus work: 2e5a2e2b-4414-5817-a455-918e464db48a
DOI: 10.1101/2022.10.25.513724

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