Article

Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

2024-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Acral melanoma (AM) is an aggressive melanoma variant that arises from palmar, plantar, and nail unit melanocytes. Compared to non-acral cutaneous melanoma (CM), AM is biologically distinct, has an equal incidence across genetic ancestries, typically presents in advanced stage disease, is less responsive to therapy, and has an overall worse prognosis. Independent analysis of published genomic an...

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Literature Corpus work: 4117c792-f240-5d61-952e-6e45b6090eeb
DOI: 10.1101/2024.06.15.599116

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