Back to search

Article

Protective anti-prion antibodies in human immunoglobulin repertoires

2020-02-05

Abstract excerpt

Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here we identified >6000 PrP-binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in detail. Antibodies directed against the flexible tail of PrP conferred neuroprotection against infectious prions. We then mined published repertoires of circulating B cells from he...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4105ba98-500a-5a51-b175-cee9f90b206f
DOI
10.1101/2020.02.05.933721
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Protective anti-prion antibodies in human immunoglobulin repertoiresDOI 10.1101/2020.02.05.933721
Autoantibodies against the prion protein in individuals with <i>PRNP</i> mutationsSemantic proximity
Autoantibodies against the prion protein in individuals with PRNP mutations.Semantic proximity
Development, High-Throughput Profiling, and Biopanning of a Large Phage Display Single-Domain Antibody LibrarySemantic proximity
Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 SequencesSemantic proximity
Discovery of diverse and functional antibodies from large human repertoire antibody librariesSemantic proximity
Monoclonal Antibody Therapeutics for Infectious Diseases: Beyond Normal Human ImmunoglobulinSemantic proximity
Guiding the Selection of Human Antibodies from Phage Display Repertoires to a Single Epitope of an AntigenSemantic proximity
Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab LibrarySemantic proximity
Isolation of Antibodies From Non-Human Primates for Clinical UseSemantic proximity
Deep Panning: Steps towards Probing the IgOmeSemantic proximity
The role of phage display in therapeutic antibody discoverySemantic proximity
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoireSemantic proximity
Select a neighboring publication to make it the new centre.