Article

Syngap1 and the development of murine neocortical progenitor cells

2024-12-20

Abstract excerpt

SYNGAP1 is a major regulator of synaptic plasticity through its interaction with synaptic scaffold proteins and modulation of Ras and Rap GTPase signaling pathways. SYNGAP1 mutations in humans are often associated with intellectual disability, epilepsy, and autism spectrum disorder. Syngap1 heterozygous loss-of-function results in impaired LTP, premature maturation of dendritic spines, learning disabilities and...

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Literature Corpus work: 41010168-6154-5ce2-8ca3-567a128067b7
DOI: 10.1101/2024.12.18.629233

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