Article

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

2022-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Polycomb Repressive Complex 2 (PRC2) establishes and maintains di- and tri-methylation at histone 3 at lysine 27 (H3K27me2/3) in the genome and plays oncogenic and tumor suppressor roles in context-dependent cancer pathogenesis. While there is clinical success of therapeutically targeting PRC2 core component, EZH2, in PRC2-dependent cancers (e.g., follicular lymphoma, epithelioid sarcoma), it re...

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Literature Corpus work: 5ed3d394-9ec1-5b3e-886d-d7fb7b2800f8
DOI: 10.1101/2022.05.28.493429

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