Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions.

doi:10.1172/jci.insight.198338

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Article

Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions.

JCI insight - 9 Feb 2026

Chong Anne-Sophie, Roca Carla, Morales-Sánchez Paula, Dorca Eduard, Barea Verónica, Ruz-Caracuel Ignacio, Valderrabano Pablo, Rovira Carlota, Jou Cristina, Bouron-Dal Soglio Dorothée, Chernock Rebecca D, Torrezan Giovana T, Pusztaszeri Marc, Cameselle-Teijeiro José M, Matias-Guiu Xavier, Alvarez Clara V, Salvador Héctor, Wasserman Jonathan D, Leandro-García Luis Javier, Foulkes William D, Andrés-León Eduardo, Casano-Sancho Paula, Rivera Barbara

Abstract excerpt

Germline and somatic changes in DICER1 and DGCR8 microprocessors confer risk of developing benign and malignant thyroid lesions, yet the molecular events driving malignant transformation remain unclear. We trace the molecular trajectories from benignity to malignancy in DICER1- and DGCR8-mutated thyroid lesions using multiomic profiling on over 30 DICER1-/DGCR8-mutated samples. Our findings reveal a progressive,...

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Identifiers

PMID: 41657311
DOI: 10.1172/jci.insight.198338
PMCID: PMC12893109

Genes

DGCR8
DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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