Article

Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications

2023-10-10

Abstract excerpt

Dravet syndrome (DS) is a devastating early onset refractory epilepsy syndrome caused by variants in the SCN1A gene. A disturbed GABAergic interneuron function is implicated in the progression to DS but the underlying developmental and pathophysiological mechanisms remain elusive, in particularly at the chromatin level. In this study, we utilized induced pluripotent stem cells (iPSCs) derived from DS cases and he...

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Literature Corpus work: 403f4e08-9b2c-55e8-ba13-3dc1964eac1d
DOI: 10.1101/2023.10.10.561691

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