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Article

Differential effects on sodium current impairments by distinct SCN1A mutations in GABAergic neurons derived from Dravet syndrome patients.

Brain & development - 1 Apr 2018

Kim Hyun Woo, Quan Zhejiu, Kim Young-Beom, Cheong Eunji, Kim Heung Dong, Cho Minjung, Jang Jiho, Yoo Young Rang, Lee Joon Soo, Kim Ji Hun, Kim Yang In, Kim Dae-Sung, Kang Hoon-Chul

Abstract excerpt

BACKGROUND: We investigated how two distinct mutations in SCN1A differentially affect electrophysiological properties of the patient-derived GABAergic neurons and clinical severities in two Dravet syndrome (DS) patients. MATERIALS AND METHODS: We established induced pluripotent stem cells from two DS patients with different mutations in SCN1A and subsequently differentiated them into forebrain GABAergic neurons....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29295803
DOI: 10.1016/j.braindev.2017.12.002

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