Back to search

Article

Engineered RVG29-Conjugated Chitosan for Enhanced Brain Delivery of Kisspeptin Agonists and Antagonists in Reproductive Health

2025-10-27

Abstract excerpt

Efficient delivery of intact therapeutic peptides across the blood–brain barrier (BBB) remains a central obstacle in translating neuroendocrine modulators to clinical practice. Kisspeptin receptor (KISS1R) agonists and antagonists precisely regulate gonadotropin-releasing hormone (GnRH) pulsatility, thereby controlling luteinizing hormone (LH) release, steroidogenesis, and fertility. While the KISS1R agonist KP10...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4038cdcc-91b1-53a7-88ad-c386d55800a9
DOI
10.1101/2025.10.26.684692
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Engineered RVG29-Conjugated Chitosan for Enhanced Brain Delivery of Kisspeptin Agonists and Antagonists in Reproductive HealthDOI 10.1101/2025.10.26.684692
Construction of a GnRH mRNA Immunocastration Vaccine and Evaluation of Its Immunogenicity and Safety in Mice and CatsSemantic proximity
Bioengineered recombinant kisspeptins with extended half-life exhibit novel peripheral function in a large-animal modelSemantic proximity
Kisspeptin across the human lifespan:evidence from animal studies and beyondSemantic proximity
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular systemSemantic proximity
Bacterial extracellular vesicles as a tunable platform for vaginal drug deliverySemantic proximity
Next Generation Therapeutic Strategies Through Smart Nanocarriers and Bioinspired Drug Delivery PlatformsSemantic proximity
Cracking the Blood–Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological TherapiesSemantic proximity
Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primatesSemantic proximity
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54Semantic proximity
Hexapeptides from a mammalian inhibitory hormone activate and inactivate nematode reproductionSemantic proximity
Microporous Immune-Isolating Capsule with Improved Diffusion for Restored Dynamic Bidirectional Hormone Signaling in a Murine Model of Premature Ovarian InsufficiencySemantic proximity
Engineered MSC-EVs Loaded with BDNF-Enhancing Neuropeptides via a Non-Disruptive Method Enhance Post-Stroke Neuroregeneration via Intranasal DeliverySemantic proximity
Select a neighboring publication to make it the new centre.