Article

Hexapeptides from a mammalian inhibitory hormone activate and inactivate nematode reproduction

2021-09-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degradation a 14-residue amino acid (aa) sequence. As a 14mer synthetic peptide (EPL001) this displayed antiproliferative and reproduction-mod...

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Literature Corpus work: 1226a078-b3e2-54b4-95f4-df0eb7911d1c
DOI: 10.1101/2021.09.28.462091

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