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Engineered MSC-EVs Loaded with BDNF-Enhancing Neuropeptides via a Non-Disruptive Method Enhance Post-Stroke Neuroregeneration via Intranasal Delivery

2025-06-05

Abstract excerpt

<title>Abstract</title> <p>Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) show potential as neuroregenerative therapies. Incorporating bioactive compounds such as neuropeptides that enhance brain-derived neurotrophic factor (BDNF) expression may amplify their therapeutic potential. We developed a clinical-scale method for loading neuropeptides into MSC-EVs, while preserving their structural integr...

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Literature Corpus work: 6ebe82c2-0c52-5035-8e56-de7499050cd1
DOI: 10.21203/rs.3.rs-6769038/v1

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Engineered MSC-EVs Loaded with BDNF-Enhancing Neuropeptides via a Non-Disruptive Method Enhance Post-Stroke Neuroregeneration via Intranasal DeliveryDOI 10.21203/rs.3.rs-6769038/v1Read

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