Article

Glucosylceramide depletion disrupts endolysosomal function in GBA-linked Parkinson’s fibroblasts?

2023-11-30

Abstract excerpt

In Gaucher and Niemann-Pick C diseases, the glucosylceramide (GlcCer) depletion hypothesis states that depletion of non-lysosomal sphingolipid pools can lead to dysfunction in the secretory and lysosomal system. The hypothesis suggests: 1) lysosomal dysfunction can be separated from lysosomal storage, 2) Lysosomal/secretory dysfunction/vATPase activity is corrected by increasing non-lysosomal GlcCer pools, and 3)...

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Literature Corpus work: 4010731e-a9d8-563e-b2ae-0953296df503
DOI: 10.1101/2023.11.30.569349

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